Creatina y función cognitiva en roedores: una revisión sistemática de la evidencia conductual y neurobiológica

of neuroinflammation through NF-κB suppression and STAT1 inhibition, and reduction of oxidative stress through CK-BB restoration. Preclinical evidence consistently supports a cognitive-enhancing role for creatine, mediated by a convergent set of energetic, synaptic, anti-inflammatory, and antioxidant mechanisms. Translating these findings to clinical applications will require brain-targeted delivery strategies, systematic consideration of sex as a biological variable, and mechanistically rigorous study designs. Copyright © 2026 The Author(s). Published by Elsevier B.V. All rights reserved.