Resumen del estudio
Further studies showed that IQ promoted IRβ/AKT-related insulin signaling, mTOR/S6K1-mediated protein synthesis, and AMPK/PGC1α-driven mitochondrial function pathway in skeletal muscle (all p < 0.05) and C2C12 myotubes (all p < 0.05). Additionally, IQ (400 mg/kg) treatment effectively reduced colon inflammation (2.58-fold lower of IL-1β) and gut barrier permeability (1.66-fold lower of ZO-1), as well as reshaped gut microbial community and modulated bile acid composition in obese mice. Overall, these results provide novel evidence that IQ supplementation has the potential for mitigating obesity-related muscle
Detalles bibliográficos
- Autores: Song Y, Dong T, Fu Z, Ao X, Zhao G, Chen Y
- Publicado en: Journal of agricultural and food chemistry
- Fecha: 2026 Apr 15
- PMID: 41937383
- DOI: 10.1021/acs.jafc.5c16221
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Esta evidencia se ha indexado automáticamente desde la base de datos PubMed (NCBI/NLM, US National Institutes of Health). El resumen mostrado es propiedad intelectual de sus autores y editorial.
