Reprogramación de la bioenergética cerebral en la depresión: un marco integrador que vincula la creatina, los aminoácidos de cadena ramificada y el ejercicio con la neuroplasticidad, la función cognitiva y los resultados relacionados con la depresión

enhancing stress resilience. Emerging empirical evidence derived from both experimental and clinical investigations suggests that the combined application of these interventions may exert complementary influences on brain bioenergetics, neuroplasticity, exercise capacity, and cognitive function. Collectively, this integrative paradigm highlights the potential of creatine supplementation, BCAAs, and physical exercise to support depression-related outcomes through distinct yet complementary mechanisms involving bioenergetic regulation, enhanced exercise capacity, neuroplastic adaptations, and improved