El metabolismo del triptófano como integrador clave dentro del eje intestino-pulmón-cerebro: Perspectivas mecanicistas y estrategias terapéuticas nutricionales para trastornos inflamatorios y neuropsiquiátricos

evidence on how Trp metabolites may function as cross-organ mediators, contributing to the "leaky gut" and "leaky brain" phenotypes. Furthermore, we evaluate the potential of precision nutrition and therapeutic interventions, including psychobiotics, dietary phytochemicals, cofactor supplementation, and fecal microbiota transplantation, to restore metabolic equilibrium. Targeting the Trp-GLB metabolic axis may therefore offer an integrative therapeutic framework for managing interconnected inflammatory and neuropsychiatric Copyright © 2026 The Authors. Published by Elsevier Masson SAS.. All rights