Una plataforma microfluídica modular hepático-microbiana para evaluar los efectos terapéuticos y adversos de los metabolitos microbianos

liver model. We compared the effects of synthetic SCFA supplementation with those of coculturing with a control and butyrate-producing E. coli Nissle 1917 (EcN) strains on hepatic steatosis. Our findings showed that live microbial coculture did not phenocopy exogenous SCFA treatment. While both treatments reduced steatotic lipid accumulation, live microbes induced inflammatory and hepatic metabolic changes, suggesting contributions from additional microbial factors, emphasizing the need to thoroughly assess side effects in liver disease © 2026 The Author(s). Advanced Healthcare Materials published by Wiley‐VCH GmbH.