Sonda fluorescente multi-analito sensible, de imagen multiorgánica, con doble emisión NIR para visualizar la disfunción hepatorrenal inducida por Hg(2+) mediada por piroptosis

polarity. In addition, VPO successfully enabled the real-time visual monitoring of these changes in mercury-exposed cells, zebrafish, and mice. Moreover, its multiresponsive property enabled the evaluation of the therapeutic efficacy of N-acetylcysteine (NAC) against Hg2+-induced hepatorenal injury. NAC alleviated hepatic and renal mitochondrial oxidative stress, as well as pyroptosis-related inflammatory signaling, by reversing Hg2+-induced biomarker abnormalities. In summary, these findings demonstrate that VPO provides a comprehensive platform for the early diagnosis, therapeutic evaluation, and mechanistic investigation