Una tendencia protectora de la N-acetilcisteína contra la hepatotoxicidad inducida por aluminio en ratas que involucra las vías Nrf2/HO-1 y NF-κB

the Nrf2/HO-1 and NF-κB pathways and reduced the nuclear translocation of Nrf2 and p65. In vivo, NAC also exhibited a beneficial protective trend in biochemical and histopathological parameters and effectively modulated the Nrf2/HO-1 and NF-κB pathways at the molecular level. In conclusion, NAC effectively scavenges reactive oxygen species, inhibits NF-κB activation, and modulates the Nrf2 pathway, thereby exerting antioxidant and anti‑inflammatory effects and demonstrating protective potential against Al‑induced Copyright © 2026 The Authors. Published by Elsevier Inc. All rights reserved.