Un modelo de farmacología de sistemas para la sobredosis de paracetamol y su tratamiento

for the release of biomarkers from injured hepatocytes to blood, and (5) a PK model for NAC and three proposed mechanisms of NAC effect. The final systems model demonstrated a good description of the concentration-time courses of paracetamol, its metabolites and biomarkers after administration of a normal dose to a large overdose of paracetamol. The final model provides a quantitative and comprehensive understanding of the causal pathway of paracetamol-induced liver toxicity and its treatment, which allows the investigation of the 'what © 2026. The Author(s), under exclusive licence to Springer Science+Business