Activación del receptor de adenosina A2B: una nueva estrategia terapéutica para acelerar la recuperación hepática tras una sobredosis de acetaminofén

their faster resolution. A2BAR activation also upregulated lipid metabolism-related genes in non-parenchymal cells and cell proliferation and metabolism genes in hepatocytes. Remarkably, genes such as Cidec and Plin2 , crucial for lipid droplet formation, were upregulated, indicating that A2ABR activation enhances lipid metabolism which plays a key role in providing energy for liver regeneration. Overall, these findings highlight the potential of A2BAR activation not only in protecting against liver injury, but also in promoting and accelerating liver regeneration by modulating the innate immune responses