El clioquinol inactiva el pirofosfato de tiamina al aumentar el estrés oxidativo celular

mitochondrial damage in a TPP-dependent manner. In an Alzheimer's disease murine model, CQ administration similarly provoked oxidative stress, decreased cerebral TPP concentrations, and induced neuronal injury. Notably, supplementation with TPP or N-acetylcysteine (NAC) mitigated CQ-associated neurotoxicity and potentiated CQ-mediated clearance of amyloid plaques. Our findings elucidate that CQ is involved in mitochondrial dysfunction and metabolic reprogramming by inactivating TPP, providing valuable insights into the neurotoxicity of CQ. Copyright © 2026 The Authors. Published by Elsevier B.V. All rights reserved.