Coadministración de vitamina D y probióticos y su mejora sinérgica de las funciones intestinales en ratas en microgravedad simulada a través de microcápsulas basadas en zeína/caseinato de sodio

of occludin (OCC), zonula occludens-1 (ZO-1) and secretory immunoglobulin A (sIgA), and further reshaped systemic immune homeostasis by reducing the production of pro-inflammatory cytokines. These benefits were associated with coordinated microbiota-barrier-immune regulation and improved VD3 metabolic signaling through activation of the vitamin D receptor (VDR) pathway. The combined microcapsules intervention outperformed single VD3 supplementation and administration of free LGG. It offers a promising strategy for maintaining intestinal health in microgravity environments and has the potential for