Los péptidos de colágeno de piel de bacalao alivian la colitis ulcerosa regulando la microbiota intestinal para inhibir la activación del inflamasoma NLRP3

insights into the underlying mechanisms. CP treatment significantly improved body weight, colon length, and histopathological scores in DSS-induced colitis mice, reduced the levels of NLRP3, Caspase-1, ASC, IL-1β, and IL-18, promoted colonic healing, and alleviated tissue damage. CP inhibited fibrosis by upregulating ZO-1 and Occludin while downregulating α-SMA, Vimentin, Snail, and Slug. In conclusion, CP may treat colitis in mice by suppressing NLRP3 inflammasome activation via regulation of the gut microbiota. © 2026 The Author(s). Food Science & Nutrition published by Wiley Periodicals