Extracción de péptidos de colágeno de piel de esturión mediada por disolvente eutéctico profundo: control del peso molecular y perspectivas mecanicistas

typical amide bands, including amide I at approximately 1630 cm-1 and amide III at 1240-1300 cm-1, confirming the collagen-derived nature of the products. Molecular simulation further suggested that oxalic acid competed for backbone hydrogen bonding, while chloride ions interacted with hydroxyproline residues, as indicated by a Hyp-Cl- radial distribution peak at 0.328 nm, promoting collagen swelling, triple-helix loosening, and controlled depolymerization. Overall, this DES-based strategy provides a rapid, tunable, and potentially sustainable route for producing collagen peptides from aquatic by-products.