El ácido docosahexaenoico aumenta la fosforilación de la tirosina hidroxilasa en Ser40 sin aumentar la expresión de la proteína tirosina hidroxilasa en células NG108-15 diferenciadas

and 6 (differentiated). Differentiation increased TH protein expression on days 5 and 6, and DHA supplementation did not affect these increases. Phosphorylation at Ser31 showed no significant change with differentiation. By contrast, phosphorylation at Ser40 exhibited a significant increase with increasing days of differentiation, and this was further augmented by DHA treatment. Collectively, these findings suggest that DHA enhances TH phosphorylation, particularly at Ser40, without affecting TH protein expression. DHA may therefore influence brain function not through changes in TH expression levels,