Effects of B vitamins and magnesium on fatigue, disease activity and quality of life in inflammatory bowel disease

Resumen del estudio

Questionnaire (IBDQ-9). Compared with placebo, the intervention produced greater reductions in ulcerative colitis (UC) activity measured by P-SCCAI (β = -1.32; p = 0.006) and fatigue assessed by IBD-F Section 1 (β = -1.98; p < 0.001) and Section 2 (β = – 5.19; p < 0.001). No significant between-group differences were observed for Crohn's disease activity (SCDAI; β = -3.93; p = 0.301) or HRQoL measured by IBDQ-9 (β = 1.21; p = 0.114). Supplementation with B vitamins and magnesium improved fatigue and symptom-based disease activity scores in UC; however, effects on underlying inflammatory activity remain uncertain.