Eficacia y seguridad de la suplementación con colágeno hidrolizado en los resultados de salud de la piel: una revisión sistemática de la literatura de ensayos controlados aleatorizados

were less consistent. HC supplementation was generally well-tolerated, with a low incidence of adverse events. QoL outcomes, assessed in seven studies primarily among osteoarthritis or rheumatoid arthritis patients, showed variable improvements depending on the assessment tool and study population. The majority of included trials were rated as having a high risk of bias. Preliminary evidence suggests that HC supplementation may offer dermatological benefits, but high-quality, standardized, adequately powered, and longer-term RCTs are needed © 2026. The Author(s), under exclusive licence to Springer Nature Limited.