Eficacia de la fibrina rica en plaquetas inyectable con regeneración tisular guiada e injerto óseo en el manejo de defectos óseos alveolares en pacientes con periodontitis crónica y deficiencia basal de vitamina D

potential to partially compensate for the impaired osteogenic capacity induced by vitamin D deficiency, the between-group differences did not reach statistical significance. Therefore, its clinical advantages require further validation in larger-sample studies. Accordingly, the routine use of i-PRF for additional clinical benefit is not recommended in patients with vitamin D deficiency; instead, vitamin D deficiency should be prioritized for correction before considering whether to combine i-PRF or other adjunctive regenerative measures. © 2026. The Author(s), under exclusive licence to The Society of The Nippon