Exploración del papel de la vitamina D en la fiebre mediterránea familiar: patogénesis, desencadenantes y modulación inmunitaria

mutations-likely reflecting Mediterranean populations more broadly-vitamin D concentrations are frequently low. This overlap raises the hypothesis that vitamin D deficiency may be associated with FMF pathogenesis, although current data are largely correlational and do not establish causality. In this review, we summarize current evidence on FMF pathogenesis, potential triggers, and vitamin D metabolism, and explore how vitamin D may modulate immune responses and intersect with key autoinflammatory pathways, considering whether adequate vitamin D supplementation could help reduce disease burden in some patients with