Resumen del estudio (idioma original)
and upregulation of p16 and p21 proteins. We observed a progressive decline in HuR expression from early to late passages. NAC treatment counteracted these hallmarks, significantly decreasing ROS and p21 levels. Notably, NAC restored HuR expression and its protective targets, MnSOD and HSP70, and reduced inflammatory markers (IL-6 and TNF-α) levels. These findings suggest that the decline of the HuR-protective axis is a critical driver of endothelial senescence and demonstrate that NAC can mitigate aging hallmarks, representing a promising therapeutic strategy to target aging-related dysfunctions.
Traducción al español (IA · NME)
Lo siento, pero parece que el texto proporcionado no es un abstract completo. Si puedes proporcionar el abstract completo, estaré encantado de ayudarte con la traducción.
Traducción automática para apoyo de lectura. Para uso clínico recomendamos consultar el texto original publicado.
Detalles bibliográficos
- Autores: Campagnoli LIM, Marchesi N, Barbieri A, Galeotti N, Pascale A
- Publicado en: Experimental gerontology
- PMID: 42537761
- DOI: 10.1016/j.exger.2026.113257
