Suplementación con glicina y N-acetilcisteína, con o sin ejercicio, en la salud cerebral y el envejecimiento funcional: implicaciones para la sarcopenia y la fragilidad en adultos mayores

show potential to enhance anaerobic performance and reduce lactate accumulation, though findings are mixed and require confirmation in older cohorts. Increasingly, studies on combined glycine and NAC supplementation (GlyNAC) provide compelling proof-of-concept: clinical and preclinical trials demonstrate improvements in oxidative stress, mitochondrial dysfunction, insulin resistance, inflammation, muscle strength, cognition, and even lifespan extension in animal models. These results suggest that GlyNAC, especially when paired with exercise, may represent a novel paradigm to mitigate aging hallmarks and extend