Estructura de prisma hexagrama compuesta de ácido hialurónico y colágeno hidrolizado como plataforma de micro-disrupción física disoluble para la administración tópica de cargas hidrofílicas

topically applied to porcine skin under varying particle numbers, rolling cycles, and mechanical loads. Treatment with five Meltryx particles, ten rolling cycles, and 1 kg load significantly increased niacinamide (as a hydrophilic model chemical) accumulation in the mid-to-deep SC layers and enhanced penetration compared with solution (control) group. These findings suggest that Meltryx generates transient micro-channels that expand diffusion pathways, enabling deeper and sustained delivery of hydrophilic actives. Meltryx represents a minimally invasive and user-friendly physical penetration enhancer