La exposición materna a ftalato de di-n-butilo promueve la fibrosis renal en crías de ratas con CIR mediante la regulación a la baja de HBB y la activación de la vía Nrf2

offspring, renal AAV-HBB delivery partially restored HBB expression and reduced DBP-associated collagen deposition, oxidative stress, and EMT-related changes. These findings indicate that maternal DBP exposure is associated with adult renal fibrotic remodeling in male offspring, with HBB downregulation, oxidative stress, NRF2-related antioxidant responses, and EMT-related alterations as key molecular features. HBB may serve as a candidate biomarker and intervention target for DBP-associated developmental nephrotoxicity, pending further Copyright © 2026 The Authors. Published by Elsevier Inc. All rights reserved.