La melatonina alivia la miocardiopatía diabética inhibiendo la senescencia celular mediante la activación de la vía de señalización MT2/SIRT1/Nrf2

activating the SIRT1/Nrf2 signaling pathway and promoting Nrf2 nuclear translocation. Notably, genetic ablation of Nrf2 in diabetic mice, as well as pharmacological inhibition of MT2, SIRT1, or Nrf2 in NRCMs, substantially abolished the protective effects of melatonin. Collectively, melatonin alleviates DCM by attenuating oxidative stress-induced cellular senescence through activation of the MT2/SIRT1/Nrf2 signaling pathway. These findings uncover a novel mechanism underlying the cardioprotective action of melatonin © 2026 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.