La N-acetilcisteína atenúa la lesión hepatorrenal inducida por mancozeb modulando el estrés oxidativo, la señalización inflamatoria y las vías apoptóticas en ratas

Bcl-2/Bax ratio were reduced. Histopathological evaluation confirmed substantial structural deterioration in both organs. NAC co-administration significantly attenuated biochemical abnormalities, restored redox balance, modulated inflammatory and apoptotic gene expression, and markedly improved tissue architecture. These findings indicate that MNZ induces hepatorenal injury through oxidative stress-associated inflammatory and apoptotic processes, and that NAC confers significant protective effects by restoring cellular redox © 2026 The Author(s). Journal of Biochemical and Molecular Toxicology published