Reprogramación transcriptómica inducida por N-acetilcisteína regula la señalización mediada por Nrf2 y la homeostasis redox en carcinoma hepatocelular experimental

effects that limit protumorigenic progression, fibrosis, and tumor cell proliferation. Notably, NAC regulates the Nrf2/Keap1 pathway enhancing antioxidant defenses and preserving biomolecular integrity. Transcriptomic analyses revealed that NAC partially restored disease-associated gene expression patterns by downregulating oncogenic pathways and genes involved in HCC development. In conclusion, these findings indicate that NAC modulates key cellular processes involved in HCC development and regulates disease-associated gene expression patterns, supporting its repositioning as a potential adjuvant