N-Acetilcisteína, Tiron y su combinación: actividades antioxidantes y antiinflamatorias in vitro y su efecto protector en un modelo de rata de colitis ulcerosa inducida por ácido acético

NAC-Tiron attenuated macroscopic and histological colonic damage, reduced inflammatory cell infiltration and edema, decreased lipid peroxidation and protein carbonylation, and helped preserve superoxide dismutase (SOD) activity, reduced glutathione (GSH), and total thiols. The treatments also attenuated increases in C-reactive protein (CRP) and free iron without evident worsening of the measured systemic biochemical parameters. Overall, these findings provide an exploratory proof of concept for fixed-ratio NAC-Tiron co-administration but do not establish pharmacological synergy or superiority over standard therapies.