El metabolismo de NAD(+) influye en los programas de transcripción asociados a TGF-β y en la microbiota intestinal en modelos murinos de colitis

alterations in TGF-β-associated and IgA-related pathways, without detectable changes in B-cell or plasma-cell abundance. In a colitis-associated cancer model, NMN administration did not significantly affect tumor number but was associated with changes in TGF-β-related immune pathways within tumors. These findings indicate that NMN supplementation is associated with changes in TGF-β-associated transcriptional and immunological networks across cellular, microbial, and tissue contexts, providing insights into the potential contribution of NAD+ metabolism in preventive approaches for fibrosis-related