El mononucleótido de nicotinamida combinado con glucosa contrarresta la disfunción mitocondrial inducida por sobrecarga de hierro en ratones bajo hipoxia hipobárica

markers including ACSL4, GPX4, and FSP1, although cannot rule out the possibility of activity alterations of these proteins. Nevertheless, NMN combined with glucose effectively reversed the ferroptosis-associated metabolic alterations and alleviated mitochondrial dysfunction. Collectively, our study provides a systems-level metabolic atlas and reveals that NMN combined glucose mitigates HH-induced multi-organ injury by suppressing ferroptosis through metabolic reprogramming, offering a therapeutic potential for high-altitude Copyright © 2026 The Authors. Published by Elsevier Inc. All rights reserved.