Memoria oxidativa en microglía: polarización persistente impulsada por OSI y su modulación por la dinámica mitocondrial (Mdivi-1)

viability versus elevated‑OSI. NAC reduced oxidative load but conferred less phenotypic recovery than Mdivi‑1. Viability remained > 80%, consistent with a sublethal stress model. Taken together, these findings indicate that a brief oxidative challenge is associated with a persistent redox-inflammatory bias in BV2 microglia that remains detectable beyond the acute exposure window. Within this experimental setting, Mdivi-1 was associated with broader phenotypic recovery than NAC, while mechanistic conclusions regarding mitochondrial © 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany,