Nanopartículas de fucoidan dirigidas a P-selectina permiten la administración combinada de NAC y el bloqueo del reclutamiento de neutrófilos en la lesión hepática inducida por acetaminofén

murine model of delayed-treatment AILI, NAC-FD NPs markedly reduced neutrophil accumulation in injured liver tissue and achieved significant therapeutic efficacy. By integrating the antioxidant activity of NAC with biointerface-mediated blockade of neutrophil recruitment, this nanoplatform simultaneously suppressed pathogenic events involved in both the early and late stages of AILI progression. These findings provide a promising biointerface-oriented strategy for the treatment of delayed-treatment AILI and broaden the therapeutic potential of targeted nanomedicine for inflammatory