La suplementación paterna con DHA antes de la concepción moldea el metabolismo lipídico de la descendencia de manera dependiente del sexo y de la dieta postnatal

revealed that sex and postnatal diet were the primary determinants of these gene expression changes, as well as strong interaction effects between sex and paternal DHA supplementation for key lipogenic genes, including GPAM, SCD1, and FAS. These results show that paternal DHA supplementation did not protect offspring from obesity or metabolic dysfunction. Instead, it induced sex- and diet-dependent programming effects of lipid metabolism driven by strong interactive influences of paternal diet, offspring sex, and postnatal Copyright © 2026 The Authors. Published by Elsevier Inc. All rights reserved.