Modulación redox-dependiente de la F(1)F(O)-ATPasa mitocondrial cardíaca y la función respiratoria por N-acetilcisteína y ascorbato de sodio

increased mitochondrial free thiol content, although no change was observed under combined treatment conditions. Mitochondrial oxygen consumption analysis revealed substrate-dependent effects of the two antioxidants on electron transport. Overall, ASC and NAC exerted distinct direct actions on isolated mitochondria, and their combination did not produce additive or synergistic effects. These findings provide new insights into the direct modulation of mitochondrial function by antioxidant compounds and may contribute to expanding understanding of their potential therapeutic and dietary supplement