La interacción entre autofagia y apoptosis mediada por ROS regula el destino celular en la microalga marina Isochrysis galbana bajo estrés por BDE-47

N-acetylcysteine (NAC) markedly attenuated both autophagy and apoptosis, identifying ROS as a common upstream trigger for both processes. Inhibition of autophagy by 3-methyladenine (3-MA) exacerbated apoptotic damage, whereas blockade of apoptosis by Z-VAD-FMK promoted autophagic activity, indicating an antagonistic crosstalk in which autophagy suppresses apoptosis and vice versa. These findings demonstrate that the ROS-autophagy-apoptosis axis is functionally conserved in a marine microalga, and provide new insight into the cellular response of marine phytoplankton to organic pollutant stress.