Modulación dirigida de enzimas biosintéticas de mediadores lipídicos como estrategia para la farmacología de la resolución de la inflamación

strategies have been developed in order to exploit the beneficial functions of SPMs for the intervention with chronic inflammatory diseases. Here, we review the promising strategy of promoting endogenous SPM formation by applying exogenous agents that activate SPM-biosynthetic enzymes, also in combination with omega-3-PUFA supplementation, for resolution pharmacology. Results from pilot clinical trials that confirm the applicability and efficacy of such agents and their combinations in patients suffering from chronic inflammatory disorders © 2026. The Author(s), under exclusive license to Springer Nature Switzerland