El efecto del uso de N-acetilcisteína en ratas preñadas expuestas a una dieta alta en grasas sobre el metabolismo de la glucosa y el estado oxidativo en las madres y su descendencia

NAC group, indicating a protective effect against oxidative stress. NAC also had a modulatory effect on oxidative stress markers such as total oxidant status, oxidative stress index, PON1, ARES and malondialdehyde. HFD induces hepatic injury and oxidative stress in both dams and their offspring, contributing to impaired metabolic programming. Maternal NAC supplementation partially ameliorated these effects by reducing oxidative damage and improving glucose metabolism. However, its protective effects were limited, particularly in restoring antioxidant enzyme activity and fully normalizing metabolic