El papel de la dieta en la patogénesis y el manejo de la insuficiencia ovárica prematura

homeostasis, epigenetic regulation, and the gut microbiota-ovarian axis. However, most available evidence is gained from observational studies and animal models. So far, the causal relationships have not yet been firmly established. Improvement in overall diet quality and appropriate supplementation of key nutrients may represent safe and potentially supportive strategies for the prevention and management of POI. Nevertheless, well-designed longitudinal studies and randomized controlled trials are required to clarify the effects of diet on ovary and to define optimal dietary intervention strategies for