El tolylfluanid induce disfunción mitocondrial y desregulación del calcio asociada al estrés oxidativo en células de trofectodermo porcino y epiteliales luminales uterinas

intracellular ROS levels and lipid peroxidation, accompanied by mitochondrial dysfunction, impaired migration, and signaling alterations. Co-treatment with N-acetylcysteine (NAC) prevented tolylfluanid-induced oxidative stress, mitochondrial dysfunction, calcium imbalance, and loss of cell viability. Collectively, these findings indicate that oxidative stress is an important contributor to the interconnected cellular alterations induced by tolylfluanid, which may affect cellular functions associated with early pregnancy. Copyright © 2026 The Authors. Published by Elsevier Inc. All rights reserved.