Resumen del estudio
pyroptosis by alleviating mitochondrial dysfunction, reducing ROS accumulation, restoring mitochondrial membrane potential, and preserving mitochondrial ultrastructure. Label-free quantitative proteomics and protein-protein interaction analysis identified KNG1 and PARP12 as key proteins associated with ROS/mPTP-mediated pyroptosis, which were validated by Western blotting. Furthermore, Connectivity Map analysis predicted four potential therapeutic agents, including RS-127445, SB-218795, proadifen, and balicatib. Collectively, these findings demonstrate that MTX induces NLRP3-dependent pyroptosis through
Detalles bibliográficos
- Autores: Cheng X, Wu H, Zhuang X, Yang B, Ding M, Gao H
- Publicado en: Biochemical pharmacology
- Fecha: 2026 May 14
- PMID: 42140447
- DOI: 10.1016/j.bcp.2026.118065
📖 Leer el estudio completo en PubMed →
Esta evidencia se ha indexado automáticamente desde la base de datos PubMed (NCBI/NLM, US National Institutes of Health). El resumen mostrado es propiedad intelectual de sus autores y editorial.
