Revelando las acciones antitumorales y el potencial terapéutico del calcitriol en el cáncer colorrectal

together may enhance immune surveillance and reduce tumor-permissive inflammation. Evidence from supplementation trials is mixed, suggesting heterogeneity in baseline vitamin D status, tumor stage and VDR pathway context. Calcitriol engages convergent epithelial and immune mechanisms that plausibly limit CRC initiation and progression, but optimal patient selection and dosing strategies remain unresolved. Future trials integrating molecular biomarkers and VDR-responsive gene signatures are needed to define when vitamin D-based Copyright © 2026 International Institute of Anticancer Research (Dr. George J.