Por qué falla el magnesio sérico: una revisión narrativa de la bioquímica del magnesio, el intercambio compartimental y la selección de puntos finales para ensayos de suplementación

three months or longer. Its within-subject reference change value of approximately 22 percent makes it unsuitable for monitoring change in an individual patient or for short interventions, a distinction that the literature has not consistently drawn.Because the expected biochemical effect of repletion is of the same order as the measurement noise, endpoint imprecision—not absence of biological effect—is a sufficient explanation for much of the null evidence in this field. Matching the assessment method to the assessment question, and reporting that choice explicitly, would advance the field without requiring new