El zinc como regulador maestro de la homeostasis de los orgánulos intracelulares

signaling pathways within each organelle. We then provide an integrated overview of how its dysregulation contributes to diverse molecular dysfunctions and pathologies including neurodegeneration, cancer, metabolic disorders and aging. We further examine emerging therapeutic strategies aimed at restoring zinc homeostasis, including supplementation and bioengineered, organelle-targeted delivery systems, as well as advanced tools for visualizing zinc dynamics at subcellular resolution. Together, these insights demonstrate the crucial role of zinc as a compartmentalized regulator of cellular health and a promising target