The effect of date seed powder supplementation on anxiety- and depression-like behaviours, sleep quality and tryptophan-kynurenine metabolism in patients with type 2 diabetes: targeting gut-brain axis

Resumen del estudio

comparison with placebo. In terms of biochemical parameters, the intervention group exhibited significantly reduced levels of endotoxin, and cortisol, KYN, KYN:TRP ratio as well as significantly elevated levels of IL-10, TRP concentrations and IL-10:IL-18 ratio compared to the placebo group. Changes in fasting sugar, C-reactive protein (hs-CRP), IL-18, ACTH, BDNF concentrations and cortisol:ACTH ratio were not different between groups. Supplementing with date seed may effectively improve anxiety- and depression-like behaviours, sleep quality and QoL by modulating metabolic endotoxemia, inflammation and HPA axis